Antisense oligonucleotides – a new generation of antimicrobials

The focus of the project “Peptide Nucleic Acids: Applications for the Inhibition of Streptococci Biofilms” is on the use and biomedical application of antisense oligonucleotides which selectively target the expression of the genes encoding enzymes for the synthesis of polysaccharides within streptococci in order to inhibit the formation of a biofilm. The project is implemented by the UAB Bioseka, the Faculty of Medicine of Vilnius University, and the Israeli biotech company GeneArrest Ltd. The project duration – 2013–2015.